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Moreover, amino acid metabolism regulates the redox balance through the generation of nicotinamide adenine dinucleotide phosphate (NADPH) and reduced glutathione (GSH), which are essential for cellular defense against oxidative stressa key driver in IPF progression [7, 19]
Changming Zhai, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
2E), indicating that the malignant cells originated mostly from basal cells
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GSH is oxidized to form GSSG, which can be reduced to GSH by the NADPH-dependent GR [28]
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