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The inhibition of p300/CBP can lead to degradation of p53 but it was not observed to a greater extent because p53 can be simultaneously acetylated by other HATs (not inhibited by curcumin) which restore its acetylation status in physiological range even after curcumin treatment

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Griese M, Latzin P, Kappler M, Weckerle K, Heinzlmaier T, Bernhardt T et al

doi: 10.1016/j.pbb.2012.03.013 87 WangX.WangW.LiL.PerryG.LeeH.-g.ZhuX

AHR increased more in the DEP group than in the control group, and increased more in the high-dose DEP group than in the low-dose DEP group at 4, 8, and 12 weeks