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An abnormal acylcarnitine profile and a high acylcarnitine to free carnitine ratio in the blood of patients with heart failure have been linked to disease severity and poor prognosis (53-55)

In addition, when circulating L-carnitine concentration increases, as in the case of oral supplementation, renal reabsorption of L-carnitine may become saturated, resulting in increased urinary excretion of L-carnitine (5)

Thus, it is uncertain whether the performance benefits observed in the present study were related to increased levels of NO or other mechanisms of action

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There is a crucial need for therapies that can lead to improved outcome after neonatal and pediatric brain injury as the currently used therapies are only partially effective [134, 135, 169172]

In general, acetylcarnitine can also act as an antioxidant to reduce high levels of ROS in the mitochondria