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[DOI] [PMC free article] [PubMed] [Google Scholar] 238.Raimondi C, et al

Clinical Studies 14.1 Mania The effectiveness of Depakote for the treatment of acute mania was demonstrated in two 3-week, placebo controlled, parallel group studies

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Although all the included studies showed the same direction of effect, we encountered high heterogeneity in our primary outcomes

Both in vitro and animal studies have demonstrated that astrocytes can synthesize KBs due to their ability to oxidize fatty acids (Yudkoff et al., 1997

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