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Development of a tool for correlational analyses Since a secondary aim of this study was to examine potential relationships between the cecal microbiome and adipose tissue metabolome, a Python (v3.8) tool, which used modules from SciPy 39 , was created to expedite the correlational analyses between the cecal microbiome and the previously-published epididymal white adipose tissue (EWAT) metabolome 13

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Cartilage degeneration was scored using the Yoshimi scale, which ranges from 0, defined as normal cartilage, to 5, defined as complete loss of cartilage

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