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Observational studies have associated alterations in cortisol patterns, such as flattened diurnal curves or elevated evening levels, with obesity, metabolic syndrome, and cardiovascular risk, though these findings do not establish causality

Methods Patients The study included 177 patients with primary IS in the carotid artery basin who were admitted in the first 1024 h after the development of neurological disorders

Key challenges for clinical translation include the lack of consistent benefit, as large RCTs and systematic meta-analyses have failed to demonstrate efficacy of prebiotics/probiotics in ICU patients despite encouraging signals in individual studies (Lee et al., 2023)