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Increased oxidative stress causes modifications of all subcellular organelles, including oxidation of endoplasmic reticulum Ca 2+ -ATPase and contractile proteins (actin and myosin being the most important) resulting in contractile dysfunction (Steinberg 2013)

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Additionally, studies should investigate EGCGs interaction with standard treatments and potential synergistic effects

doi: 10.3389/fmed.2022.795839 [DOI] [PMC free article] [PubMed] [Google Scholar] 45.Pereira JEG, El Dib R, Braz LG, et al

These headaches often feel like a tight band of pressure around the forehead, temples, or back of the head, and may be especially noticeable after waking up

Overall, vitamin D exerts renoprotective effects in CKD by modulating ROS generation, enhancing antioxidant capacity, and preserving mitochondrial function, closely intersecting with its roles in immune and inflammatory regulation