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(ii) major medical problems, including cardiac, liver, endocrine, or renal disease

Cellular GSH level is maintained by a complex homeostatic mechanism, among which glutamate cysteine ligase (GCL), consisting of catalytic (GCLC) and regulatory (GCLM) subunits, plays major roles in GSH synthesis

There is no current evidence that existing small peptide or non-peptide BDNF mimetics promote survival through inactivation of BAD proteins in various damaging cell context considering the available data

Therefore, BPC-157 PEN can be described as a research reagent of broad relevance in tissue biology analyses and preclinical models

Science 265 (5170), 346355