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Through precise NNMT inhibition, nicotinamide regulation, and NAD+ elevation, the product is widely used in research on hepatic metabolic disorders and fatty liver disease, supporting mechanistic dissection and drug development

in 2018 (PMID: 29155147) in Biochemical Pharmacology

Grip strength increased by approximately 60% when the compound was combined with rigorous exercise training, compared to about 25% improvement from either exercise or treatment alone

NNMT is upregulated in adipose tissue in obesity, and its inhibition is studied as a potential strategy to modulate NAD+ metabolism and metabolic gene expression

This improvement in strength was accompanied by enhanced muscle endurance and accelerated recovery from muscle injury, indicating comprehensive restoration of muscle function rather than isolated effects