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Description
Knockout of prolyl hydroxylase domain-containing protein 2 (PHD2) stabilized HIF-1 protein and activated HIF-1 signaling, which transcriptionally upregulated glutaminase 1 ( GLS1 ) expression leading to a decrease in ROS production and increases in cellular GSH levels, GSH/GSSG, and cell survival in murine periosteal progenitor cells, suggesting that HIF-1 signaling promotes glutaminolysis to provide glutamate for GSH synthesis (96)
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Rheumatoid Arthritis and Oxidative Stress

Glutamate metabolism in major depressive disorder

10.1016/s0016-5085(99)70510-x 14
Rarely reported side effects include: Before you take this supplement, tell your healthcare provider if you: Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements
