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Consequently, these macrophages lose their capacity to kill intracellular pathogens through the IFN- pathway ( 4.3 Lipid peroxidation in UC In 2000, Millar discovered that the use of iron chelators significantly reduced ROS in the colon tissues of UC patients, thereby improving clinical symptoms and endoscopic findings in UC ( 2+ accumulates, and excess Fe 2+ reacts with H 2 O 2 in the cells to produce the Fenton reaction, generating -OH

Following this period, the mice were randomly divided into five treatment groups ( n = 5 per group): PBS, Mn/TI@mHSA, P-Mn@mHSA, P-Mn/TI@mHSA-N and P-Mn/TI@mHSA group, with the doses equivalent for 4 mg kg 1 of Mn/TI@mHSA

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Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement