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As of February 18, 2026, the class has expanded with established agents like semaglutide, liraglutide, dulaglutide, and exenatide, alongside dual GLP-1/GIP agonists such as tirzepatide, which are often discussed in GLP-1 contexts due to overlapping mechanisms and indications

The response was dose-dependent, with higher doses producing slightly more fat loss, though the dose-response curve flattened at higher levels (Thompson et al., 2004)

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It is also involved in regulating various bodily functions and protecting against oxidative stress