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In bovine aortic endothelial cells (BAECs), pharmacological blockers of flow-sensitive K + channels attenuate important endothelial responses to flow including release of both cGMP [53] and NO [54], upregulation of transforming growth factor beta 1 (TGF- 1 ) [55], and endothelial nitric oxide synthase (eNOS) [56] mRNA levels, and downregulation of endothelin-1 protein expression (Figure 2) [25, 57]

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AOD 9604 is a modified peptide fragment of human growth hormone (HGH), specifically a stabilized version of amino acids 176191 of the HGH molecule