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Molecular studies presented in the book focus on the regulation of these enzymes and identify important response elements

Recent investigations have also indicated AKGs potential to support tissue repair and reduce toxin-induced cellular damage, making it a valuable addition to detoxification formulas (Iqbal et al., 2021)

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To mimic ChaC1 overexpression by inducing endogenous ChaC1 high expression, a complementary ChaC1-induction-based screening was performed and revealed proteasome inhibitors (e.g., bortezomib, ixazomib, delanzomib) as potent inducers of endogenous ChaC1 via ATF4-dependent transcriptional activation