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The value of sample fractionation is demonstrated by a 2005 report describing mass spectrometric profiling of hippocampal plasma membrane fractions (Nielsen et al., 2005)

The study of cell death patterns is very important for elucidating the molecular mechanism of disease occurrence

doi:10.1136/bmjopen-2015-008222 Goto F, Nakai K, Kunihiro T, Ogawa K

doi: 10.1186/s12199-017-0634-7

1999 Feb

In addition, activation of Smad2/3 by NLRP3 phosphorylates vascular endothelial cells and transforms them into myofibroblasts, thereby increasing the production of -SMA and MMP9 [199]
