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Methods Adults with previously untreated, high-risk HER2-positive eBC (T3 or node-positive [N13], including inflammatory disease) were randomized 1:1:1 to: T-DXd-THP: T-DXd 5.4 mg/kg every 3 weeks 4 cycles THP 4 cycles (n=321) ddAC-THP: Doxorubicin + cyclophosphamide every 2 weeks 4 cycles THP 4 cycles (n=320) T-DXd alone: 5.4 mg/kg every 3 weeks 8 cycles (n=286) The primary endpoint was pathologic complete response (pCR

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10.1016/j.yrtph.2020.104665 80 Zemba CilicA.ZembaM.CilicM.BalenovicI.StrbeS.IlicS

Or is the story a bit more complex

Cells acquire cysteine mainly by macrophage and lymphocyte uptake, and impaired immune responses are associated with a reduction in GSH concentration (Drge and Breitkreutz, 2000

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