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doi: 10.1016/j.vaccine.2019.04.020 347 WeckxL

Among the environmental factors involved in the pathogenesis of ASD, prenatal exposure to the antiepileptic drug valproic acid (VPA) has been repeatedly associated with increased risk of neurodevelopmental delay and autistic symptoms in the offspring ( Although the mechanisms by which VPA interferes with development causing autistic-like features in the exposed offspring need to be still elucidated, an imbalance between GABAergic and glutamatergic neurotransmission has been reported, which is also implicated in ASD etiology ( Increased oxidative stress has been identified as a possible mechanism through which environmental factors exert their deleterious effects on the developing brain ( N-acetylcysteine (NAC) is a synthetic derivative of the endogenous amino acid L-cysteine that is able to modulate glutamatergic neurotransmission and the excitatory/inhibitory ratio (34)

Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV secretion components

By reducing this inflammatory burden, GHK-Cu creates a more favorable environment for tissue regeneration and maintenance

Increased oxidative stress is a key driving mechanism in perpetuating inflammation and lung injury

10.33393/dti.2024.3060 14 BardynM.TissotJ
