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Live imaging was conducted at intervals of 5 ~ 6 days to monitor the progression of the disease

The pathological PNI status was assessed according to the definition proposed by Liebig [8]: cancer cell in close proximity to nerve and involving at least 33% of its circumference or tumor cells within any of the 3 layers of the nerve sheath

In contrast, Western-style diets high in refined sugars, saturated fats, and processed foods tend to promote oxidative stress, insulin resistance, and low-grade inflammation, thereby exacerbating cognitive decline over time [129]

Pioglitazone even at low dosage improves NAFLD in type 2 diabetes: clinical and pathophysiological insights from a subgroup of the TOSCA.IT randomised trial

These include men who follow strict vegetarian or vegan diets (especially for B12), those with chronic digestive issues that affect nutrient absorption, and men over 50 whose absorption naturally decreases with age

This challenge is further compounded by disease-associated BBB dysfunction that does not occur uniformly throughout disease progression