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While its suppression alleviates chronic inflammation, complete inhibition of NF-B signaling has been shown to impair osteoblast proliferation, migration, and early differentiation, suggesting that its therapeutic targeting must be finely tuned in terms of dosage, timing, and pathway specificity

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Moreover, ONOO cause protein oxidation and nitration, leading to cellular injury [77]

In a study conducted in 1998, Vogelstein et al

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