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In addition, the conversion of sepiapterin to BH 4 requires DHFR activity, therefore, in states in which the activity or expression of DHFR is reduced, sepiapterin supplementation may be ineffective [196]
doi: 10.3390/ijms18102137 99 SongBLiPYanSLiuYGaoMKLvHYet al
doi:10.1056/NEJMcp1014163 19
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