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In post-hoc analyses, where the reference population was restricted to inpatients, the adjusted HR for hypothyroidism was 3.4 (2.7-4.4

The absence of adverse effects in rodent models is a promising indicator, not a guarantee of equivalent safety in human subjects

hence, after validation and optimization, glutathione in the biological samples was determined

A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment