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Rate constants k obs were plotted against the substrate concentration in SigmaPlot 13.0 to obtain second order rate constants from the slopes of the linear fits or first-order rate constants from hyperbolic fits

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3.2 Long-term HPT axis dysfunction and fertility impairment What evidence exists regarding long-term disturbances of the hypothalamicpituitarytesticular axis and fertility impairment following anabolicandrogenic substance abuse