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doi: 10.1136/gutjnl-2020-322473, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 68

[DOI] [PubMed] [Google Scholar] Ryabinin AE, Tsoory MM, Kozicz T, et al

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Mood and Hormonal Regulation Influences dopaminergic and serotonergic pathways May alleviate depressive symptoms and improve seasonal affective disorder (SAD) Supports testosterone and estrogen balance indirectly through hormone-sensitive tissues Clinical Use Cases Severe or chronic vitamin D deficiency requiring parenteral correction Supportive therapy in patients with osteoporosis, osteomalacia, or low BMD Prevention of falls and fractures in geriatric populations Adjunct in immune or chronic inflammatory conditions Post-bariatric or GI surgery nutrient repletion Hormonal health optimization (e.g., male and female HRT protocols) Dosage and Administration Route : Intramuscular only typically administered into the gluteal muscle Dosage : Clinician-determined based on baseline 25(OH)D level and maintenance goals Common protocols include weekly or monthly dosing 1 mL = 500 IU