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Approximately 38% of acivicin-affected genes are also similarly affected by the daf-2 mutation (Fig

Collectively, these molecular modifications engender a self-reinforcing cycle of mitochondrial dysfunction, oxidative damage, and inflammation that expedites the deterioration of both muscular and vascular systems

This finding indicates that epigenetic variation, which may well be susceptible to contextual and other environmental influences, has a greater effect on serum UA than the identified genetic factors and certainly deserves further investigation in PD

A brief review