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Mitochondria, which are key organelles in maintaining cellular homeostasis, adenosine triphosphate (ATP) production, regulation of apoptosis, and the cells response to oxidative stress, appear to be particularly vulnerable to hypoxic damage

The integrated PK-PD findings, including nonlinear exposure, target tissue accumulation, and disruption of L-carnitine homeostasis, collectively elucidate mildronates mechanism of action through energy substrate depletion, as well as its intrinsic efficacy-toxicity duality

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Les radicaux libres sont des molcules instables gnres par des facteurs de stress environnementaux tels que les rayons UV, la pollution et le tabagisme

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