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A large international study suggests that a subset of people with Type 2 diabetes carry genetic variants that blunt the effectiveness of widely used GLP-1based drugs, despite unexpectedly elevated levels of the hormone in their bodies

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This review article examines the translational evolution of glucagon-like peptide-1 receptor agonists (GLP-1RAs), tracing their progression from the discovery of exendin-4 in Gila monster venom to long-acting peptide analogues and the first orally delivered peptide therapy, oral semaglutide