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Tivantinib (ARQ197) displays Cytotoxic activity that is independent of its ability to bind MET

28 , 29 The loss of DKK1, a WNT signaling inhibitor, further reduces autophagic activity, driving stromal cells to differentiate into myofibroblasts and promoting ECM accumulation

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[DOI] [PubMed] [Google Scholar] 215.Loeser RF, Pacione CA, and Chubinskaya S, The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes

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