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Research highlights that these mitochondrial changes are driven by hyperglycemia-induced ROS, leading to bioenergetic deficits in neuronal cells

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In the brain itself, changes are less severe: they occur as small sources of nervous fibers decay and accumulation of astrocytes, usually subcortically located, an also round hemorrhages with a torus of glial cells

The cortex itself is divided into three zones: the zona glomerulosa , the zona fasciculata , and the zona reticularis

Additionally, vitamin E was also shown to inhibit the production of inflammatory mediators such as prostaglandin E2 (PGE 2 ), interleukin (IL)-6 or tumor necrosis factor (TNF)- in aged mice, particularly in response to pathogens [23]

It should be used strictly as directed by a healthcare provider