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Together they reduce binding affinity to the six IGF binding proteins (IGFBP-1 through IGFBP-6) by approximately one to two orders of magnitude, while preserving full agonist activity at the type 1 IGF receptor

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Cell Biochem Funct 29:4349 Sugiura H, Okita S, Kato T, Naka T, Kawanishi S, Ohnishi S et al (2013) Protection by taurine against INOS-dependent DNA damage in heavily exercised skeletal muscle by inhibition of the NF-B signaling pathway