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CD38 inhibitors derived from 4-amino-quinoline The availability of data from crystallography of CD38, and a better understanding of its mechanism of catalysis, paved the road for the design of new high affinity and more specific CD38 inhibitors [78-79]
NNMT inhibition as a metabolic and epigenetic research target
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Interestingly, even in studies where beta-3 receptors were absent, some metabolic effects persisted with acute dosing, suggesting secondary mechanisms may exist
