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Description
IGF1 combines with IGF1R, activates the Ras/MEK signaling pathway, and promotes the expression of transcription factors, such as E2F, Foxo3a, and ELK (Reuter et al., 2010), thereby promoting cell proliferation
10.3390/molecules26102954
Serious treatment-related adverse events occurred in 20 of 125 patients (16%) in the cabozantinib group and 1 of 62 patients (2%) in the placebo group
In addition, the stress-responsive transcription factor ATF4 upregulates ASNS, ASS1, PHGDH, and SLC1A5 [216], as well as PKM2 and HK2 [322]
American Journal of Human Genetics
[DOI] [PMC free article] [PubMed] [Google Scholar] 270.Livanos AE, et al
