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DSVs actively generate hydrogen sulfide (H2S) through sulfate reduction by utilizing sulfate as an electron acceptor during the respiration and increase H2S production, which causes severe damage to the CNS (78)

We also see many individuals who follow strict vegetarian or vegan diets, which can increase the risk of B12 deficiency due to limited intake of animal-derived foods

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In addition to iron uptake, after crossing the outer membrane, zinc uptake is facilitated by a periplasmic binding protein and a homologous membrane permease system ZnuABC (also called MntABC in the literature), and mutants unable to produce any of these proteins are defective in intracellular survival (Lim et al., 2008)