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In addition, cancer cells can internalize extracellular ATP through macropinocytosis and other endocytic mechanisms, contributing to a 1.5-2 times increase in intracellular ATP levels relative to normal cells (54, 56)

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& Galatenko, N

We visualized single-cell data via principal component analysis (PCA) considering only the expression of proteins associated with cellular metabolism (GLUT1, HK, GAPDH, LDHA, G6PD, CD98, CS, ATP5A, CD36, CPT1A, ACADM, ACLY, FASN, SCD1, LAL, mTOR, pAKT, pS6, AMPK), and determined that CAR T cells from STR and LTR have distinct metabolic states (Fig

doi: 10.3389/fcimb.2021.676456 51 BahASanicasMNigouJGuilhotCAstarie-DequekerCVergneI