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Its overactivation disrupts nicotinamide metabolism, reduces NAD+ levels, promotes hepatic lipid accumulation and lipotoxicity, and represents an important therapeutic target for hepatic metabolic disorders

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FIGURE 1 Signal transduction pathway, serving as the foundation for various cellular functions such as proliferation, differentiation, apoptosis, metabolism, oxidative stress, and immune response, facilitates the transmission of extracellular signaling molecules to the cell via cell membrane or intracellular receptors