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The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]

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Like NAD, glutathione exists in two states: reduced (GSH) and oxidized glutathione disulfide (GSSG)

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Rats were housed under a 12-hour light/dark cycle with unlimited access to food and water

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Acetic acid water is sterile water with 0.1 to 1.0% dilute acetic acid added

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