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Description
By using fats as energy for muscle contractions, the body is sparing glycogen and also delaying the accumulation of lactic acid in muscles
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In fact, OSBP is one of several such proteins, including OSBP9 and GRAMD1s/Asters (GRAMD1a/GRAMD1b/GRAMD1c)
Although it could be theoretically possible to enhance the reverse cholesterol effects of LXRs without targeting hepatic lipogenesis with the use of LXR-specific ligands since most of the hepatic responses are due to activation of LXR, this will be a difficult challenge as the ligand binding pocket in both isoforms has been shown to be nearly identical
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The volume of distribution (Vd) can be calculated by dividing the administered dose by the phenobarbital level
