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These are unlikely to be caused by structural abnormalities, as recovery soon follows restoration of euglycemia
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Revisiting inflammation in bipolar disorder

Their impact is aggravated by their chronicity and comorbidity and the insufficient efficacy of current treatments

In mice, treatment with wortmannin, a PI3K inhibitor, or an AKT1/2 inhibitor decreased sortilin protein levels and increased plasma cholesterol and TAG (186)

Clinical trials also show that acetyl-l-carnitine supplementation is more effective than a placebo in improving depression symptoms
