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ERS prompts IRE1 to autophosphorylate, switching on its RNase domain to excise a short intron from X-box-binding protein-1 (XBP1) mRNA and generate two products: the spliced form XBP1s and the unspliced precursor XBP1u (99)

p Values were adjusted for multiple comparisons using Holms step-down Bonferroni correction

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