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Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway

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and to treat heart disease, including congestive heart failure, and chest pain (angina)

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Yang SJ, Choi JM, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY (2014) Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes
