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Both compounds do not cross the blood-brain-barrier (BBB), although paclitaxel is accumulated in dorsal root ganglion neuronswhich lie outside the BBBvia largely unknown mechanisms (Cavaletti et al., 1997, 2000

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doi: 10.3389/fnut.2026.1711478 Received 23 September 2025 Revised 03 February 2026 Accepted 11 February 2026 Published 11 March 2026 Volume 13 - 2026 Edited by Patrick Nol Pallier, Queen Mary University of London, United Kingdom Reviewed by Alexander P

These agents mitigated the cytotoxic effects of RSL3-induced GPX4 inhibition in each cell line and of erastin-induced GPX4 inhibition in M-Wnt and metM-Wnt lung cells (Fig