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Furthermore, Grill and co-workers (1987) presented a time course of PC induction and GSH consumption after 200 M Cd(NO 3 ) 2 to a Rauvolfia serpentina cell suspension culture, showing a fast response in which GSH is decreased because it is used as a substrate for PC [69]

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P = 0.038)

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Although many agents have been shown to modulate autophagy in preclinical models, direct assessment in human clinical samples has rarely been performed

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