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METTL3-SETMAR-SMARCA2-TF axis Most thyroid cancer patients have well-differentiated PTC, but in some cases, the disease may later transform into PDTC or even ATC, which significantly worsens the prognosis [64]

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While ferroptosis can be immunogenic under certain conditions, the concurrent risk of fostering an immunosuppressive TME necessitates a rationally designed combination strategy