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The juxta-epithelial region shows the presence of diffuse melanin pigmentation along with the presence of melanocytes and melanophages (macrophages that engulf the melanin pigment)

Nevertheless, among 65 patients with primary retroperitoneal dedifferentiated liposarcoma, 5-year disease-specific survival was only 20% and 3-year local and distant recurrence-free survival was 17% and 70%, respectively

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PMID 11762491