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These pathways include the cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis 1,4 , the ferroptosis suppressor protein 1 (FSP1)/coenzyme Q 10 (CoQ 10 ) axis on the plasma membrane 5,6 , the guanosine triphosphate cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) axis 7,8 , and the mitochondrial dihydroorotate dehydrogenase (DHODH)/CoQ system 9

For example, a prior research constructed a transgenic mouse model overexpressing HO-1 presenting with clinical symptoms resembling those of PD patients in humans ( 4.5 Acetylcholinesterase activity (AChE) Patients with concurrent symptoms of reduced salivation and dry mouth have been observed as a consequence of employing AChE as a diagnostic biomarker for PD

Eur J Pharmacol 2020;888:173574

J Mol Neurosci 75 , 17 (2025)

Research shows that glutathione can help to reduce neurodegenerative disease, promote cartilage health, ward off age-related changes in the eye, improve immune function, and maintain more youthful skin