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Interestingly, the use of other metabolic substrates, such as pyruvate or acetate, did not protect OGD-exposed neurons 53 suggesting that lactate-mediated post-ischemic neuroprotection cannot be solely attributed to its proposed role as a metabolic fuel for neurons, but may also involves other unknown complementary mechanisms

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Whether that reshuffling translates into anything functional, into real changes in how a cell ages, behaves, or secretes molecules, is a separate question each study has to test on its own terms

WHO global estimates showed that the rate of obesity has nearly tripled between 1975 and 2016 [110]

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Proc Natl Acad Sci USA 107:38763881 [DOI] [PMC free article] [PubMed] [Google Scholar] Jeong S (2017) Molecular and cellular basis of neurodegeneration in Alzheimers disease