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DHA can be rapidly degraded to 2,3-diketogulonic acid by reactive hydrolysis, the molecules thus losing their vitamin property

Heresco-Levy, U., Ermilov, M., Lichtenberg, P., Bar, G

D., Dizdaroglu, M

10.3322/caac.21204 226 ParmarM

This high binding capacity allows FR to transport folate against a concentration gradient at levels as low as 0.1 nM [5, 26], roughly ten times lower than required transport via RFC [2, 3], making it the most efficient plasma membrane folate transporter identified

By binding to G-actin, TB-500 maintains a pool of actin monomers that prevent the premature hardening of the cellular skeleton