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Consistently, LiPMS measurements of purified eGFPRCC2 revealed an FBP-mediated conformational change within RCC2 (Fig

The use of folic acid for the treatment of pernicious anemia patients began with the availability of synthetic folic acid in 1945 (79)

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Evidence showed that excess intracellular hydrogen peroxide regulates the expression of various NF-B component proteins, and the alterations in the composition or quantity of the NF-B dimer can change down-stream target gene expression, and conduce to the upregulation of pro-inflammatory genes and a pro-apoptotic environment ( In summary, we investigated the role of GPX1 in protecting SGNs against oxidative stress by upregulating or inhibiting the expression of GPX1 in SGNs via the GPX1 mimic ebselen or the gpx1 knockout mouse model, and further determined the mechanistic details behind the neuroprotective effect of GPX1 in SGNs against peroxynitrite injury

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