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The use of a methyl group is optimum in that it is small enough to not influence the overall activity of the molecule, while the rationale behind the location of the modification is to protect the most common degradation location of the peptides, i.e., the peptide bond

[4] N-acetylcysteine may be used in oral, intravenous or topical routes

Niosomes were used in treatment of some dermatologic diseases to increase the bioavailability of the used drugs and to decrease its side effects

PLoS ONE 9:e113526