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Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan

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Additional exploratory applications include neuroprotection through enhanced brain energy metabolism and immune modulation, as preliminary work suggests anti-inflammatory actions in experimental models

143 A mitochondria-targeting nanoplatform was recently developed by conjugating folic acid-modified MCNs with the bioactive peptide M27-39, achieving dual therapeutic effects against both colorectal cancer and IBD

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In inflammatory bowel disease models, BPC-157 reduced the severity of experimentally induced colitis in rats when administered either intraperitoneally or intraluminally, suggesting activity through both systemic and local routes (Sikiric et al., 1993