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doi: 10.1016/j.chom.2013.08.003 37 TsuangMTStoneWSFaraoneSV

In a recent phase Ib clinical trial focusing on domatinostat (a dual inhibitor of LSD1/HDAC) in patients with advanced melanoma, the drug failed to enhance the efficacy of treatments targeting anti-PD-1 and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) while unexpected severe skin toxicity was observed
doi: 10.1016/0016-5085(87)90619-6

Here, peptides access the brain through olfactory epithelial cells and then further along the olfactory and trigeminal nerve pathways for more distal brain delivery in a non-invasive manner (Figure 1) [14]

doi: 10.1002/glia.20557, 27 BrownA

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